Prof. Dr. Stefan Zahler

Adjunct Professor
Group Leader
Head of Imaging Facility

Contact

University of Munich
Department of Pharmacy - Center for Drug Research
Pharmaceutical Biology
Butenandtstr. 5-13
81377 Munich
Germany

Office: B 4.002

Room: B 4.002
Phone: +49-89-2180-77196
Fax: +49-89-2180-77170
Email: stefan.zahler@cup.uni-muenchen.de

Project description

Angiogenesis, the formation of new blood vessels is important for physiological (e.g. wound healing) and pathological (e.g. tumor growth) processes.

We are interested in inhibiting angiogenesis mainly in the tumor context as very promising therapeutic option. The molecular target structures we currently investigate are the kinase CDK5 and the cytoskeleton proteins tubulin and actin.

By using and characterizing novel inhibitors of natural origin (e.g. isolated from myxobacteria) we gain insight into basic cell biological questions, and try to establish innovative classes of potential therapeutics.

In a further approach, we try to understand basic concepts of angiogenesis by manipulating cellular behaviour via nanoagents. like, e.g. structured surfaces, hygrogels, nanoparticles or artificial membranes.

Group members

Dr. Christina Jayachandran

Dr. Maibritt Kretschmer