Contact
Department of Pharmacy - Center for Drug Research
Pharmaceutical Biology
Butenandtstr. 5-13
81377 Munich
Germany
Office: B 4.002
Room:
B 4.002
Phone:
+49-89-2180-77196
Fax:
+49-89-2180-77170
Email:
stefan.zahler@cup.uni-muenchen.de
Project description
Angiogenesis, the formation of new blood vessels is important for physiological (e.g. wound healing) and pathological (e.g. tumor growth) processes.
We are interested in inhibiting angiogenesis mainly in the tumor context as very promising therapeutic option. The molecular target structures we currently investigate are the kinase CDK5 and the cytoskeleton proteins tubulin and actin.
By using and characterizing novel inhibitors of natural origin (e.g. isolated from myxobacteria) we gain insight into basic cell biological questions, and try to establish innovative classes of potential therapeutics.
In a further approach, we try to understand basic concepts of angiogenesis by manipulating cellular behaviour via nanoagents. like, e.g. structured surfaces, hygrogels, nanoparticles or artificial membranes.
Group members
Current funding
SFB 1032: 'Controlling cellular functions by structured surfaces. (Artificial angiogenesis)'.
Responsibilities
Head of the Imaging Facility of the Department of Pharmacy
Publications
An up-to-date list of Prof. Dr. Zahler's publications can be found on PubMed.