Department of Pharmacy - Center for Drug Research
Office: B 4.013
Archazolid is a myxobacterial compound inhibiting the function of the v-ATPase, a proton pump responsible for pH regulation throughout most eukaryotic cells. It is found to be overexpressed in a variety of tumor cells correlating with the treatment resistance of these cells. The aim of this project is to analyze the mechanisms leading to archazolid-induced apoptosis and growth inhibition of highly metastatic tumor cells and to characterize the role of v-ATPase in these processes.
An up-to-date list of Dr. von Schwarzenberg's publications can be found on PubMed.