Department of Pharmacy - Center for Drug Research
Room: B 4.025
Cancer-related diseases are still a major cause of death, however therapy remains challenging and cure is rarely achieved. Our group is interested in the function of the endolysosomal system (ES) in the development and treatment of cancer. The ES is essential for the regulation of cellular transport, which is of pivotal importance for cellular migration. Additionally it mediates recycling and repair processes that maintain cellular homeostasis and energy generation. Tumor cells depend on this delicate homeostasis to facilitate growth, survival and metastasis formation, rendering the ES as an interesting anti-cancer target. One major aim is to analyze the role of endolysosmal cation channel families, in particular mucolipins (TRPMLs) and two-pore channels (TPCs), in cancer and to explore these channels as new drug targets. The second main goal is to exploit modulators of ES function as tools to investigate its role in cancer, especially its influence on other cellular organelles, in order to develop new therapeutic strategies.
An up-to-date list of Dr. Bartel´s publications can be found on PubMed